Management of levodopa-induced jig-like gait disorder with pallidal stimulation

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Comparison of pallidal and subthalamic deep brain stimulation for the treatment of levodopa-induced dyskinesias.

Deep brain stimulation (DBS) can relieve dyskinesias effectively and safely. This modality is applied most commonly in the treatment of dyskinesias associated with levodopa therapy for Parkinson disease. The subthalamic nucleus (STN) and globus pallidus internus (GPi) are the most common surgical targets. Deep brain stimulation of the GP has a direct antidyskinetic effect, whereas relief of dys...

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Levodopa-Induced Dyskinesia: Medical and Surgical Management

Although levodopa therapy remains the most effective symptomatic treatment for PD, its usefulness may be limited by these motor complications, which result in deterioration in quality of life. Levodopa-induced dyskinesia (LID) is characterized by a variety of hyperkinetic movements. Although chorea and dystonia are the most common manifestations of LID, stereotypies, tics, myoclonus, or ballism...

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Carbidopa-levodopa-induced recrudescence of premorbid tic disorder in remission.

Sir: Dopamine agonists, such as carbidopa-levodopa, have utility in alleviating symptoms of movement disorders , e.g., parkinsonism, and can reduce distressing movement disturbances arising from a variety of other conditions , e.g., restless legs syndrome, and tremor arising from head injury. We report a case illustrating that utilization of a dopamine agonist can precipitate tics in a patient ...

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Paradoxical worsening of gait with levodopa in Parkinson disease.

Neurology 2012;78:446–447 Despite many recent advances in the treatment of Parkinson disease (PD), levodopa is still the most effective medication for PD. While there are many “nondopaminergic” features of PD that do not improve with levodopa, PD motor symptoms generally improve with dopaminergic medications. However, not all the motor manifestations of PD are improved to the same extent and so...

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Effects of subthalamic nucleus stimulation and levodopa treatment on gait abnormalities in Parkinson disease.

BACKGROUND Stimulation of the subthalamic nucleus is proposed for the treatment of patients presenting with severe Parkinson disease. The effect on gait is not clearly established. OBJECTIVES To evaluate objectively the influence of bilateral subthalamic nucleus stimulation on gait in Parkinson disease and to compare it with the effects of levodopa treatment. METHODS Ten patients underwent ...

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ژورنال

عنوان ژورنال: Neurology: Clinical Practice

سال: 2014

ISSN: 2163-0402,2163-0933

DOI: 10.1212/cpj.0000000000000054